000			04524cam a2200529 i 4500
001			13175856
003			MiTN
005			20190729110620.0
008			160926s2017 nyuaf b 001 0 eng c
010			_a 2016044189
024	8		_a40027047113
035			_a(DLC) 2016044189
040			_aDNLM/DLC _beng _erda _cDLC _dNLM _dOCLCQ _dOCLCO _dUPZ _dOCLCA _dOCLCF _dVTL _dGL4 _dCPL _dYDX _dYDX _dOCLCO _dZLM _dFM0 _dABG _dIGA _dTXWBR _dNDS _dNRG _dOCLCO _dUIU _dVP@
020			_a9780525427537 _q(hardback)
020			_a0525427538 _q(hardback
020			_z9780698177789 _q(ebook)
042			_apcc
043			_an-us---
050	0	4	_aRA644.R8 _bW33 2017
060	0	0	_a2017 B-697
060	1	0	_aWC 11 AA1
100	1		_aWadman, Meredith,
245	1	4	_aThe vaccine race : _bscience, politics, and the human costs of defeating disease / _cMeredith Wadman.
264		1	_aNew York, New York : _bViking, an imprint of Penguin Random House LLC, _c[2017]
264		4	_c©2017
300			_a436 pages, 16 unnumbered pages of plates : _billustrations ; _c24 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references (pages 415-419) and index.
505	0		_aBeginnings -- Discovery -- The Wistar reborn -- Abnormal chromosomes and abortions -- Dying cells and dogma -- The Swedish source -- Polio vaccine "Passengers" -- Trials -- An emerging enemy -- Plague of the pregnant -- Rabies -- Orphans and ordinary people -- The devils we know -- Politics and persuasion -- The great escape -- In the bear pit -- Cell Wars -- DBS defeated -- Breakthrough -- Slaughtered babies and Skylab -- Cell, Inc. -- Rocky passage -- The vaccine race -- Biology, Inc. -- Hayflick's limit explained -- Boot-camp bugs and Vatican entreaties -- The afterlife of a cell -- Where they are now.
520			_aUntil the late 1960s, tens of thousands of American children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant; there was no vaccine and little understanding of how the disease devastated fetuses. In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman's account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who "owns" research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives.
650		0	_aRubella vaccines _xResearch _zUnited States _xHistory _y20th century.
650		0	_aRubella vaccines _xPolitical aspects _zUnited States _xHistory _y20th century.
650		0	_aRubella _xVaccination _xHistory _y20th century.
650		0	_aMMR vaccine _xResearch _zUnited States _xHistory _y20th century.
650		0	_aHuman experimentation in medicine _zUnited States _xHistory _y20th century.
650		0	_aHuman experimentation in medicine _xPolitical aspects _zUnited States _xHistory _y20th century.
650	1	2	_aMeasles-Mumps-Rubella Vaccine _xhistory.
650	2	2	_aHuman Experimentation _xhistory.
650	2	2	_aHistory, 20th Century.
651		2	_aUnited States.
776	0	8	_iOnline version: _aWadman, Meredith. _tVaccine race. _dNew York, New York : Viking, [2016] _z9780698177789 _w(DLC) 2016045456
596			_a1
948			_au620783
903			_a34254
999			_c34254 _d34254