000			02941nam a2200421 i 4500
001			2015002906
003			DLC
005			20190729110309.0
008			150123s2015 mdu b 001 0 eng
010			_a 2015002906
020			_a9781421418018 (hardcover : alk. paper)
020			_a1421418010 (hardcover : alk. paper)
020			_z9781421418025 (electronic)
020			_z1421418029 (electronic)
035			_a(DNLM)101650220
040			_aDNLM/DLC _cDLC _erda _dMiTN
042			_apcc
050	0	0	_aRC582 _b.P38 2015
060	1	0	_aQW 540
082	0	0	_a616.07/9 _223
100	1		_aPaul, William E.,
245	1	0	_aImmunity / _cWilliam E. Paul.
264		1	_aBaltimore : _bJohns Hopkins University Press, _c[2015]
300			_axiii, 260 pages : _billustrations ; _c24 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505			_aPart 1. Immunology -- 1. Defense and danger -- 2. Tracing an immune response -- 3. The laws of immunology: universality, tolerance, and appropriateness -- 4. Growing up and learning immunology -- Part 2. The first law: universality -- 5. Vaccines and serum therapy -- 6. How is specificity achieved? -- 7. Immunology's "eureka": clonal selection -- 8. How does each lymphocyte develop a distinct receptor? -- 9. B cells and T cells recognize different types of antigens -- 10. My foray into the specificity problem -- 11. Genes and immune response -- 12. The Laboratory of Immunology and the T-cell receptor -- Part 3. The second law: tolerance -- 13. What is tolerance? -- 14. How does tolerance develop? -- 15. Regulatory T cells and the prevention of autoimmunity -- Part 4. The third law: appropriateness -- 16. Different structures, different functions -- 17. Specific types of infections, specific types of T-cell responses -- 18. Our discovery of IL-4 and the cells that make it -- 19. CD8 T cells: killer cells and friends -- 20. Dendritic cells: the cells that interpret the infectious threat -- Part 5. How did the immune system evolve? -- 21. An "ancient" immune response controls "modern" immunity -- 22. The microbiome and innate immunity -- 23. Evolution of the immune system and innate lymphoid cells -- Part 6. AIDS, autoimmunity, allergy, cancer, and transplantation -- 24. The HIV epidemic and the Office of AIDS Research -- 25. How the immune system causes rheumatoid arthritis and lupus -- 26. Allergy and asthma -- 27. Interleukin-4 and allergy -- 28. Can the immune system control cancer? -- 29. New parts for old: bone marrow and organ transplantation -- 30. Julien -- Conclusion. The future of immunology.
650	0	0	_aImmunity.
650	0	0	_aImmune system.
650	0	0	_aImmunologic diseases.
948			_au604258
949			_aRC582 .P38 2015 _wLC _c1 _hEY8Z _i33039001361764
596			_a1
903			_a32407
999			_c32407 _d32407