000			03281nam a2200409 i 4500
001			2015016478
003			DLC
005			20190729110308.0
008			150507s2015 nyu b 001 0 eng
010			_a 2015016478
020			_a9780199362585 (hardback)
040			_aDLC _beng _erda _cDLC _dMvI
042			_apcc
050	0	0	_aRS420 _b.L535 2015
084			_aMED071000 _aSCI013060 _2bisacsh
082	0	0	_a615.1 _223
100	1		_aLi, Jie Jack.
245	1	0	_aTop drugs : _bhistory, pharmacology, syntheses / _cJie Jack Li.
264		1	_aNew York, NY : _bOxford University Press, _c2015.
300			_axi, 206 pages : _bcharts ; _c25 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
520			_a"Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery"-- _cProvided by publisher.
520			_a"A thorough examination of the chemistry and history of ten prominent prescription drugs"-- _cProvided by publisher.
504			_aIncludes bibliographical references and index.
505	8		_aMachine generated contents note: -- Table of Contents -- CARDIOVASCULAR DRUGS -- Chapter 1 Atorvastatin Calcium (Lipitor) -- Chapter 2 Clopidogrel (Plavix) -- Chapter 3 Amlodipine (Novasc) -- CANCER DRUGS -- Chapter 4 Paclitaxel (Taxol) -- Chapter 5 Imatinib (Gleevec) -- DRUGS FOR METABOLIC DISEASES -- Chapter 6 Sitagliptin (Januvia) -- CNS DRUGS -- Chapter 7 Sertraline (Cymbalta) -- Chapter 8 Olanzapine (Zyprexa) -- DRUGS TO TREAT INFECTIOUS DISEASES -- Chapter 9 Sofosbuvir (Sovaldi) -- ULCER DRUGS -- Chapter 10 Esomeprazole (Nexium).
650		0	_aDrugs _xHistory.
650		0	_aDrugs _xDesign.
650		0	_aPharmaceutical chemistry.
650		7	_aMEDICAL / Pharmacology. _2bisacsh
650		7	_aSCIENCE / Chemistry / Industrial & Technical. _2bisacsh
948			_au604248
949			_aRS420 .L535 2015 _wLC _c1 _hEY8Z _i33039001361665
596			_a1
903			_a32397
999			_c32397 _d32397